PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane

PI(3,4,5)P3 + H2O → PI(3,4)P2 + Pi

Reactome

R-HSA-1675949

Compartment

plasma membrane · cytosol

Rhea

None recorded

Catalysed by

• phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity of INPP5(2) [cytosol]EC 3.1.3.86

Literature

1. Identification and characterization of a novel inositol polyphosphate 5-phosphatase J Biol Chem, 2000
2. Identification of a novel domain in two mammalian inositol-polyphosphate 5-phosphatases that mediates membrane ruffle localization. The inositol 5-phosphatase skip localizes to the endoplasmic reticulum and translocates to membrane ruffles following epidermal growth factor stimulation J Biol Chem, 2003
3. Cloning and expression of a human placenta inositol 1,3,4,5-tetrakisphosphate and phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase Biochem Biophys Res Commun, 1996
4. Multiple forms of an inositol polyphosphate 5-phosphatase form signaling complexes with Shc and Grb2 Curr Biol, 1996
5. Novel inositol polyphosphate 5-phosphatase localizes at membrane ruffles J Biol Chem, 1999
6. The phosphatidylinositol polyphosphate 5-phosphatase SHIP1 associates with the dok1 phosphoprotein in bcr-Abl transformed cells Cell Signal, 2000