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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane

ATP + PI4P → ADP + PI(3,4)P2

Reactome: R-HSA-1676206
Compartment: early endosome membrane · cytosol
Rhea: None recorded

Inputs

ATPCHEBI:30616, C10H12N5O13P3, cytosol
PI4PCHEBI:17526, C11H18O16P2R2, early endosome membrane

Outputs

ADPCHEBI:456216, C10H12N5O10P2, cytosol
PI(3,4)P2CHEBI:16152, C11H19O19P3R2, early endosome membrane

Catalysed by

1-phosphatidylinositol-4-phosphate 3-kinase activity of PIK3C2A:Ca2+/Mg2+ [cytosol]EC 2.7.1.154

Literature

PI3KC2?, a class II PI3K, is required for dynamin-independent internalization pathways J Cell Sci, 2010
Class II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptors Mol Cell Biol, 2000