PA is converted to CDP-DAG by CDS2
PA + CTP → CDP-DAG + PPi
- Reactome
- R-HSA-1483165
- Compartment
- mitochondrial inner membrane · mitochondrial matrix
- Rhea
- None recorded
Inputs
- PACHEBI:57739, C5H5O8PR2, mitochondrial inner membrane
- CTPCHEBI:37563, C9H12N3O14P3, mitochondrial matrix
Outputs
- CDP-DAGCHEBI:58332, C14H17N3O15P2R2, mitochondrial inner membrane
- PPiCHEBI:33019, HO7P2, mitochondrial matrix
Catalysed by
- phosphatidate cytidylyltransferase activity of CDS2 [mitochondrial inner membrane]EC 2.7.7.41; UniProt O95674
Literature
- The role of CDP-diacylglycerol synthetase and phosphatidylinositol synthase activity levels in the regulation of cellular phosphatidylinositol content J Biol Chem, 1997
- Cardiolipin is synthesized on the matrix side of the inner membrane in rat liver mitochondria J Biol Chem, 1993
- Participation of the microsomal CDP-diglycerides in the mitochondrial biosynthesis of phosphatidylglycerol Biochem Cell Biol, 1986