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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

MLCL is hydrolyzed to DLCL by PLA2G4A (IM)

MLCL + H2O → DLCL + LCFA(-)

Reactome: R-HSA-1482759
Compartment: mitochondrial inner membrane · mitochondrial matrix
Rhea: None recorded

Inputs

MLCLCHEBI:60430, C12H19O16P2R3, mitochondrial inner membrane
H2OCHEBI:15377, H2O, mitochondrial matrix

Outputs

DLCLCHEBI:75137, C11H18O15P2R2, mitochondrial inner membrane
LCFA(-)CHEBI:57560, CO2R, mitochondrial inner membrane

Catalysed by

A2-type glycerophospholipase activity of PLA2G4A:Ca2+ [mitochondrial inner membrane]EC 3.1.1.4

Literature

Cardiolipin hydrolysis by human phospholipases A2. The multiple enzymatic activities of human cytosolic phospholipase A2 Biochim Biophys Acta, 1998
Serine 228 is essential for catalytic activities of 85-kDa cytosolic phospholipase A2 J Biol Chem, 1994