PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane

PI(4,5)P2 + ATP → PI(3,4,5)P3 + ADP

Reactome

R-HSA-1676048

Compartment

plasma membrane · cytosol

Rhea

RHEA:21292

Catalysed by

• 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity of PIK3C(1) [cytosol]EC 2.7.1.153

Literature

1. The G beta gamma sensitivity of a PI3K is dependent upon a tightly associated adaptor, p101 Cell, 1997
2. p84, a new Gbetagamma-activated regulatory subunit of the type IB phosphoinositide 3-kinase p110gamma Curr Biol, 2005
3. Cloning of human p55 gamma, a regulatory subunit of phosphatidylinositol 3-kinase, by a yeast two-hybrid library screen with the insulin-like growth factor-I receptor Gene, 1998
4. Characterization of p87PIKAP, a novel regulatory subunit of phosphoinositide 3-kinase gamma that is highly expressed in heart and interacts with PDE3B J Biol Chem, 2006
5. P110delta, a novel phosphoinositide 3-kinase in leukocytes Proc Natl Acad Sci U S A, 1997
6. Cloning, expression, purification, and characterization of the human Class Ia phosphoinositide 3-kinase isoforms Protein Expr Purif, 2004