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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane

PI4P + ATP → PI(4,5)P2 + ADP

Reactome: R-HSA-1676082
Compartment: plasma membrane · cytosol
Rhea: RHEA:14425

Inputs

PI4PCHEBI:17526, C11H18O16P2R2, plasma membrane
ATPCHEBI:30616, C10H12N5O13P3, cytosol

Outputs

PI(4,5)P2CHEBI:58456, C11H14O19P3R2, plasma membrane
ADPCHEBI:456216, C10H12N5O10P2, cytosol

Catalysed by

1-phosphatidylinositol-4-phosphate 5-kinase activity of PIP5K1A-C [cytosol]EC 2.7.1.68

Literature

Phosphatidylinositol-4-phosphate 5-kinase isozymes catalyze the synthesis of 3-phosphate-containing phosphatidylinositol signaling molecules J Biol Chem, 1997
Recruitment and regulation of phosphatidylinositol phosphate kinase type 1 gamma by the FERM domain of talin Nature, 2002
A role for PtdIns(4,5)P2 and PIP5Kalpha in regulating stress-induced apoptosis Curr Biol, 2006
Regulation and cellular roles of phosphoinositide 5-kinases Eur J Pharmacol, 2004
Phospholipase D signaling: orchestration by PIP2 and small GTPases Naunyn Schmiedebergs Arch Pharmacol, 2007