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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

Data

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

PG transports from the ER membrane to the late endosome membrane

PG → PG

Reactome: R-HSA-1483218
Compartment: endoplasmic reticulum membrane · late endosome membrane
Rhea: RHEA:39743

Inputs

PGCHEBI:64716, C8H12O10PR2, endoplasmic reticulum membrane

Outputs

PGCHEBI:64716, C8H12O10PR2, late endosome membrane

Literature

De novo biosynthesis of the late endosome lipid, bis(monoacylglycero)phosphate J Lipid Res, 2007
A lipid associated with the antiphospholipid syndrome regulates endosome structure and function Nature, 1998
Late endosomal membranes rich in lysobisphosphatidic acid regulate cholesterol transport Nat Cell Biol, 1999
Short-range intracellular trafficking of small molecules across endoplasmic reticulum junctions Trends Cell Biol, 2004
Membrane contacts between endosomes and ER provide sites for PTP1B-epidermal growth factor receptor interaction Nat Cell Biol, 2010