2-acyl LPC is acylated to PC by LPCAT

2-acyl LPC + acyl-CoA → PC + CoA-SH

Reactome

R-HSA-1482533

Compartment

endoplasmic reticulum membrane · cytosol

Rhea

RHEA:10332

Catalysed by

• 2-acylglycerol-3-phosphate O-acyltransferase activity of LPCAT [endoplasmic reticulum membrane]EC 2.3.1.52

Literature

1. Molecular identification of a novel mammalian brain isoform of acyl-CoA:lysophospholipid acyltransferase with prominent ethanolamine lysophospholipid acylating activity, LPEAT2 J Biol Chem, 2008
2. Cloning and characterization a novel human 1-acyl-sn-glycerol-3-phosphate acyltransferase gene AGPAT7 DNA Seq, 2005
3. Lysophospholipid acyltransferases and arachidonate recycling in human neutrophils J Biol Chem, 2008
4. Cloning and characterization of mouse lung-type acyl-CoA:lysophosphatidylcholine acyltransferase 1 (LPCAT1). Expression in alveolar type II cells and possible involvement in surfactant production J Biol Chem, 2006
5. Identification and characterization of a lysophosphatidylcholine acyltransferase in alveolar type II cells Proc Natl Acad Sci U S A, 2006
6. A single enzyme catalyzes both platelet-activating factor production and membrane biogenesis of inflammatory cells. Cloning and characterization of acetyl-CoA:LYSO-PAF acetyltransferase J Biol Chem, 2007