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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

Data

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

1-acyl LPE is acylated to PE by LPEAT

1-acyl LPE + acyl-CoA → PE + CoA-SH

Reactome: R-HSA-1482667
Compartment: endoplasmic reticulum membrane · cytosol
Rhea: None recorded

Inputs

1-acyl LPECHEBI:29017, C6H13NO7PR, endoplasmic reticulum membrane
acyl-CoACHEBI:58342, C22H31N7O17P3SR, cytosol

Outputs

PECHEBI:57613, C7H12NO8PR2, endoplasmic reticulum membrane
CoA-SHCHEBI:57287, C21H32N7O16P3S, cytosol

Catalysed by

1-acylglycerol-3-phosphate O-acyltransferase activity of LPEAT [endoplasmic reticulum membrane]EC 2.3.1.51

Literature

Discovery of a lysophospholipid acyltransferase family essential for membrane asymmetry and diversity Proc Natl Acad Sci U S A, 2008
Identification and characterization of a major liver lysophosphatidylcholine acyltransferase J Biol Chem, 2008
Characterization of human lysophospholipid acyltransferase 3 J Lipid Res, 2009
Lysophospholipid acyltransferases and arachidonate recycling in human neutrophils J Biol Chem, 2008
Molecular identification of a novel mammalian brain isoform of acyl-CoA:lysophospholipid acyltransferase with prominent ethanolamine lysophospholipid acylating activity, LPEAT2 J Biol Chem, 2008
Substrate preferences of a lysophosphatidylcholine acyltransferase highlight its role in phospholipid remodeling Lipids, 2008