PI is exchanged with PC by PITPNB
PI:PITPNB + PC → PI + PC:PITPNB
- Reactome
- R-HSA-1483087
- Compartment
- Golgi membrane
- Rhea
- None recorded
Inputs
- PI:PITPNBR-HSA-1524150, Golgi membrane
- PCCHEBI:57643, C10H18NO8PR2, Golgi membrane
Outputs
- PICHEBI:57880, C11H16O13PR2, Golgi membrane
- PC:PITPNBR-HSA-1524122, Golgi membrane
Catalysed by
- phosphatidylcholine transfer activity of PI:PITPNB [Golgi membrane]
Literature
- Dynamics of lipid transfer by phosphatidylinositol transfer proteins in cells Traffic, 2008
- Phosphatidylinositol- and phosphatidylcholine-transfer activity of PITPbeta is essential for COPI-mediated retrograde transport from the Golgi to the endoplasmic reticulum J Cell Sci, 2010
- Structure of a multifunctional protein. Mammalian phosphatidylinositol transfer protein complexed with phosphatidylcholine J Biol Chem, 2001
- Structure of PITPbeta in complex with phosphatidylcholine: comparison of structure and lipid transfer to other PITP isoforms Biochemistry, 2005
- Structure of apo-phosphatidylinositol transfer protein alpha provides insight into membrane association EMBO J, 2002
- Structure-function analysis of human [corrected] phosphatidylinositol transfer protein alpha bound to phosphatidylinositol Structure, 2004