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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

PE is methylated to PC by PEMT

PE + 3 AdoMet → PC + 3 AdoHcy

Reactome: R-HSA-1483174
Compartment: endoplasmic reticulum membrane · cytosol
Rhea: None recorded

Inputs

PECHEBI:57613, C7H12NO8PR2, endoplasmic reticulum membrane
3 AdoMetCHEBI:59789, C15H23N6O5S, cytosol

Outputs

PCCHEBI:57643, C10H18NO8PR2, endoplasmic reticulum membrane
3 AdoHcyCHEBI:57856, C14H20N6O5S, cytosol

Catalysed by

phosphatidylethanolamine N-methyltransferase activity of PEMT [endoplasmic reticulum membrane]EC 2.1.1.17; UniProt Q9UBM1

Literature

Activity of phosphatidylethanolamine-N-methyltransferase in brain affected by Alzheimer's disease Neurochem Int, 1999
The methylation of phosphatidylethanolamine Prog Lipid Res, 1988
Structure, expression profile and alternative processing of the human phosphatidylethanolamine N-methyltransferase (PEMT) gene Biochim Biophys Acta, 2001