PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane
PI5P + ATP → PI(4,5)P2 + ADP
- Reactome
- R-HSA-1675776
- Compartment
- plasma membrane · cytosol
- Rhea
- RHEA:12280
Inputs
- PI5PCHEBI:57795, C11H15O16P2R2, plasma membrane
- ATPCHEBI:30616, C10H12N5O13P3, cytosol
Outputs
- PI(4,5)P2CHEBI:58456, C11H14O19P3R2, plasma membrane
- ADPCHEBI:456216, C10H12N5O10P2, cytosol
Catalysed by
- 1-phosphatidylinositol-5-phosphate 4-kinase activity of PIP4K2 dimers [cytosol]EC 2.7.1.149
Literature
- Localization of phosphatidylinositol phosphate kinase IIgamma in kidney to a membrane trafficking compartment within specialized cells of the nephron Am J Physiol Renal Physiol, 2008
- A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate Nature, 1997
- Localization, regulation and function of type II phosphatidylinositol 5-phosphate 4-kinases Adv Enzyme Regul, 2010
- Evolutionarily conserved structural changes in phosphatidylinositol 5-phosphate 4-kinase (PI5P4K) isoforms are responsible for differences in enzyme activity and localization Biochem. J., 2013
- The function of phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) explored using a specific inhibitor that targets the PI5P-binding site Biochem. J., 2015