Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

TAG is hydrolyzed to DAG by PNPLA2/3

TAG + H2O → DAG + LCFA(-)

Reactome: R-HSA-1482777
Compartment: endoplasmic reticulum membrane · cytosol
Rhea: None recorded

Inputs

TAGCHEBI:17855, C6H5O6R3, endoplasmic reticulum membrane
H2OCHEBI:15377, H2O, cytosol

Outputs

DAGCHEBI:17815, C5H6O5R2, endoplasmic reticulum membrane
LCFA(-)CHEBI:57560, CO2R, endoplasmic reticulum membrane

Catalysed by

triacylglycerol lipase activity of PNPLA2/3 [endoplasmic reticulum membrane]EC 3.1.1.3

TAG is hydrolyzed to DAG by PNPLA2/3

Inputs

Outputs

Catalysed by

Literature