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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

MTMR12 binds MTM1

MTM1 + MTMR12 → MTM1:MTMR12

Reactome: R-HSA-6809680
Compartment: cytosol
Rhea: None recorded

Inputs

MTM1R-HSA-1604646, cytosol
MTMR12R-HSA-6809657, cytosol

Outputs

MTM1:MTMR12R-HSA-6809679, cytosol

Catalysed by

phosphatase activator activity of MTMR12 [cytosol]

Literature

Identification of myotubularin as the lipid phosphatase catalytic subunit associated with the 3-phosphatase adapter protein, 3-PAP Proc. Natl. Acad. Sci. U.S.A., 2003
Loss of catalytically inactive lipid phosphatase myotubularin-related protein 12 impairs myotubularin stability and promotes centronuclear myopathy in zebrafish PLoS Genet., 2013
Isolation and characterization of two 3-phosphatases that hydrolyze both phosphatidylinositol 3-phosphate and inositol 1,3-bisphosphate J. Biol. Chem., 1991