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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane

H2O + PI(4,5)P2 → PI4P + Pi

Reactome: R-HSA-1675824
Compartment: Golgi membrane · cytosol
Rhea: RHEA:22764

Inputs

H2OCHEBI:15377, H2O, cytosol
PI(4,5)P2CHEBI:58456, C11H14O19P3R2, Golgi membrane

Outputs

PI4PCHEBI:17526, C11H18O16P2R2, Golgi membrane
PiCHEBI:43474, HO4P, cytosol

Catalysed by

phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity of OCRL/INPP5E [cytosol]EC 3.1.3.36

Literature

Cloning and characterization of a 72-kDa inositol-polyphosphate 5-phosphatase localized to the Golgi network J Biol Chem, 2000
Mutations in INPP5E, encoding inositol polyphosphate-5-phosphatase E, link phosphatidyl inositol signaling to the ciliopathies Nat Genet, 2009
The isolation and characterization of a cDNA encoding phospholipid-specific inositol polyphosphate 5-phosphatase J Biol Chem, 2000
Differential clathrin binding and subcellular localization of OCRL1 splice isoforms J Biol Chem, 2009
Lowe syndrome, a deficiency of phosphatidylinositol 4,5-bisphosphate 5-phosphatase in the Golgi apparatus Hum Mol Genet, 1995
The protein deficient in Lowe syndrome is a phosphatidylinositol-4,5-bisphosphate 5-phosphatase Proc Natl Acad Sci U S A, 1995