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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

PI(3,5)P2 is dephosphorylated to PI5P by the MTMR2:SBF2 tetramer at the plasma membrane

PI(3,5)P2 + H2O → PI5P + Pi

Reactome: R-HSA-6809944
Compartment: plasma membrane · cytosol
Rhea: RHEA:39019

Inputs

PI(3,5)P2CHEBI:57923, C11H14O19P3R2, plasma membrane
H2OCHEBI:15377, H2O, cytosol

Outputs

PI5PCHEBI:57795, C11H15O16P2R2, plasma membrane
PiCHEBI:43474, HO4P, cytosol

Catalysed by

phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity of MTMR2:SBF2 Tetramer [cytosol]EC 3.1.3.95

Literature

Multi-level regulation of myotubularin-related protein-2 phosphatase activity by myotubularin-related protein-13/set-binding factor-2 Hum. Mol. Genet., 2006