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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane

PI(4,5)P2, PI(3,4)P2, PI(3,4,5)P3 + H2O → PI5P, PI3P, PI(3,5)P2 + Pi

Reactome: R-HSA-8849969
Compartment: cytosol · early endosome membrane
Rhea: None recorded

Inputs

PI(4,5)P2, PI(3,4)P2, PI(3,4,5)P3R-ALL-8849959, early endosome membrane
H2OCHEBI:15377, H2O, cytosol

Outputs

PI5P, PI3P, PI(3,5)P2R-ALL-8849958, early endosome membrane
PiCHEBI:43474, HO4P, cytosol

Catalysed by

phosphatidylinositol phosphate 4-phosphatase activity of INPP5F [early endosome membrane]UniProt Q9Y2H2

Literature

Sac2/INPP5F is an inositol 4-phosphatase that functions in the endocytic pathway J. Cell Biol., 2015