p-Y389,400-RUFY1 binds RAB4A:GTP, RAB5:GTP, RAB14:GTP
p-Y389,400-RUFY1 + RAB14:GTP + RAB4A:GTP + RAB5A:GTP → p-Y389,400-RUFY1:p-Y389,400-RUFY1:RAB4A:GTP:RAB5:GTP:RAB14:GTP
- Reactome
- R-HSA-8871366
- Compartment
- early endosome membrane
- Rhea
- None recorded
Inputs
- p-Y389,400-RUFY1R-HSA-5215951, early endosome membrane
- RAB14:GTPR-HSA-8871377, early endosome membrane
- RAB4A:GTPR-HSA-8871367, early endosome membrane
- RAB5A:GTPR-HSA-2130191, early endosome membrane
Outputs
- p-Y389,400-RUFY1:p-Y389,400-RUFY1:RAB4A:GTP:RAB5:GTP:RAB14:GTPR-HSA-8871353, early endosome membrane
Catalysed by
- protein-macromolecule adaptor activity of p-Y389,400-RUFY1 [early endosome membrane]
Literature
- RUFY, Rab and Rap Family Proteins Involved in a Regulation of Cell Polarity and Membrane Trafficking Int J Mol Sci, 2013
- Characterization of the role of the Rab GTPase-activating protein AS160 in insulin-regulated GLUT4 trafficking J. Biol. Chem., 2005
- Rabip4' is an effector of rab5 and rab4 and regulates transport through early endosomes Mol. Biol. Cell, 2004
- The Rab4 effector Rabip4 plays a role in the endocytotic trafficking of Glut 4 in 3T3-L1 adipocytes J. Cell. Sci., 2006
- Functional cross-talk between Rab14 and Rab4 through a dual effector, RUFY1/Rabip4 Mol Biol Cell, 2010