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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

PCTP binds PC

PCTP + PC → PCTP:PC

Reactome: R-HSA-8873794
Compartment: cytosol
Rhea: None recorded

Inputs

PCTPR-HSA-5215990, cytosol
PCCHEBI:57643, C10H18NO8PR2, cytosol

Outputs

PCTP:PCR-HSA-8873866, cytosol

Catalysed by

phosphatidylcholine binding activity of PCTP [cytosol]UniProt Q9UKL6

Literature

Structure of human phosphatidylcholine transfer protein in complex with its ligand Nat. Struct. Biol., 2002
PC-TP/StARD2: Of membranes and metabolism Trends Endocrinol. Metab., 2010
Phosphatidylcholine transfer protein interacts with thioesterase superfamily member 2 to attenuate insulin signaling Sci Signal, 2013
Thioesterase superfamily member 2 (Them2) and phosphatidylcholine transfer protein (PC-TP) interact to promote fatty acid oxidation and control glucose utilization Mol. Cell. Biol., 2014