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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

Data

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

PE is hydrolyzed to 1-acyl LPE by PLA2[16]

PE + H2O → 1-acyl LPE + LCFA(-)

Reactome: R-HSA-1602398
Compartment: extracellular region · plasma membrane
Rhea: None recorded

Inputs

PECHEBI:57613, C7H12NO8PR2, plasma membrane
H2OCHEBI:15377, H2O, extracellular region

Outputs

1-acyl LPECHEBI:29017, C6H13NO7PR, plasma membrane
LCFA(-)CHEBI:57560, CO2R, plasma membrane

Catalysed by

A2-type glycerophospholipase activity of PLA2(16) [extracellular region]EC 3.1.1.4

Literature

Cloning and recombinant expression of a structurally novel human secreted phospholipase A2 J Biol Chem, 2000
Studies on prophospholipase A2 and its enzyme from human pancreatic juice. Catalytic properties and sequence of the N-terminal region Eur J Biochem, 1982
Interfacial kinetic and binding properties of the complete set of human and mouse groups I, II, V, X, and XII secreted phospholipases A2 J Biol Chem, 2002
Cloning and recombinant expression of phospholipase A2 present in rheumatoid arthritic synovial fluid J Biol Chem, 1989
Cloning and characterization of novel mouse and human secretory phospholipase A(2)s J Biol Chem, 1999
Structures, enzymatic properties, and expression of novel human and mouse secretory phospholipase A(2)s J Biol Chem, 2000