Skip to content

DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

Data

Loading the map…

Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

2-MAG is hydrolyzed to fatty acid and glycerol by MGLL

2-MAG + H2O → Glycerol + fatty acid

Reactome: R-HSA-1482543
Compartment: endoplasmic reticulum membrane · cytosol
Rhea: RHEA:44688

Inputs

2-MAGCHEBI:17389, C4H7O4R, endoplasmic reticulum membrane
H2OCHEBI:15377, H2O, cytosol

Outputs

GlycerolCHEBI:17754, C3H8O3, cytosol
fatty acidCHEBI:35366, CHO2R, endoplasmic reticulum membrane

Catalysed by

monoacylglycerol lipase activity of MGLL dimer [endoplasmic reticulum membrane]EC 3.1.1.23

Literature

Full mass spectrometric characterization of human monoacylglycerol lipase generated by large-scale expression and single-step purification J Proteome Res, 2008
RNA interference suggests a primary role for monoacylglycerol lipase in the degradation of the endocannabinoid 2-arachidonoylglycerol Mol Pharmacol, 2004
Crystal structure of the human monoacylglycerol lipase, a key actor in endocannabinoid signaling Chembiochem, 2010
Structural basis for human monoglyceride lipase inhibition J Mol Biol, 2010