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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

DDHD1,2 hydrolyse PA

PA + H2O → 1-acyl LPA + LCFA(-)

Reactome: R-HSA-6786650
Compartment: cytosol · plasma membrane
Rhea: None recorded

Inputs

PACHEBI:57739, C5H5O8PR2, plasma membrane
H2OCHEBI:15377, H2O, cytosol

Outputs

1-acyl LPACHEBI:16975, C4H8O7PR, plasma membrane
LCFA(-)CHEBI:57560, CO2R, plasma membrane

Catalysed by

glycerophospholipase activity of DDHD1,2 [cytosol]EC 3.1.1

Literature

Roles of SAM and DDHD domains in mammalian intracellular phospholipase A1 KIAA0725p Biochim. Biophys. Acta, 2012
Alteration of fatty-acid-metabolizing enzymes affects mitochondrial form and function in hereditary spastic paraplegia Am. J. Hum. Genet., 2012
A novel phospholipase A1 with sequence homology to a mammalian Sec23p-interacting protein, p125 J. Biol. Chem., 2002
Mutations in DDHD2, encoding an intracellular phospholipase A(1), cause a recessive form of complex hereditary spastic paraplegia Am. J. Hum. Genet., 2012