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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
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Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

THEM86B hydrolyses PMCHO, PMETAM

PMCHO, PMETAM + H2O → fatty aldehyde + GPCHO, GPETAM

Reactome: R-HSA-8874435
Compartment: endoplasmic reticulum membrane · cytosol
Rhea: None recorded

Inputs

PMCHO, PMETAMR-ALL-8874447, endoplasmic reticulum membrane
H2OCHEBI:15377, H2O, cytosol

Outputs

fatty aldehydeCHEBI:35746, CHOR, cytosol
GPCHO, GPETAMR-ALL-8874450, endoplasmic reticulum membrane

Catalysed by

ether hydrolase activity of TMEM86B [endoplasmic reticulum membrane]EC 3.3.2; UniProt Q8N661

Literature

Purification, identification, and cloning of lysoplasmalogenase, the enzyme that catalyzes hydrolysis of the vinyl ether bond of lysoplasmalogen J. Biol. Chem., 2011
Dysregulation of Plasmalogen Homeostasis Impairs Cholesterol Biosynthesis J. Biol. Chem., 2015