PI4P is dephosphorylated to PI by SYNJ at the plasma membrane
PI4P + H2O → PI + Pi
- Reactome
- R-HSA-1675988
- Compartment
- plasma membrane · cytosol
- Rhea
- RHEA:55652
Inputs
- PI4PCHEBI:17526, C11H18O16P2R2, plasma membrane
- H2OCHEBI:15377, H2O, cytosol
Outputs
- PICHEBI:57880, C11H16O13PR2, plasma membrane
- PiCHEBI:43474, HO4P, cytosol
Catalysed by
- phosphatidylinositol phosphate 4-phosphatase activity of SYNJs,OCRL [cytosol]
Literature
- InsP3-mediated intracellular calcium signalling is altered by expression of synaptojanin-1 Biochem J, 2004
- SAC1-like domains of yeast SAC1, INP52, and INP53 and of human synaptojanin encode polyphosphoinositide phosphatases J Biol Chem, 1999
- Synaptojanin 2, a novel Rac1 effector that regulates clathrin-mediated endocytosis Curr Biol, 2000
- The dual phosphatase activity of synaptojanin1 is required for both efficient synaptic vesicle endocytosis and reavailability at nerve terminals Neuron, 2007