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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap
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PI4P is dephosphorylated to PI by SYNJ at the plasma membrane

PI4P + H2O → PI + Pi

Reactome
R-HSA-1675988
Compartment
plasma membrane · cytosol
Rhea
RHEA:55652

Inputs

Outputs

Catalysed by

  • phosphatidylinositol phosphate 4-phosphatase activity of SYNJs,OCRL [cytosol]

Literature

  1. InsP3-mediated intracellular calcium signalling is altered by expression of synaptojanin-1 Biochem J, 2004
  2. SAC1-like domains of yeast SAC1, INP52, and INP53 and of human synaptojanin encode polyphosphoinositide phosphatases J Biol Chem, 1999
  3. Synaptojanin 2, a novel Rac1 effector that regulates clathrin-mediated endocytosis Curr Biol, 2000
  4. The dual phosphatase activity of synaptojanin1 is required for both efficient synaptic vesicle endocytosis and reavailability at nerve terminals Neuron, 2007