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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap
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MFSD2A transports LPC from extracellular region to plasma membrane

LPC (22:6) + Na+ → LPC (22:6) + Na+

Reactome
R-HSA-8865637
Compartment
extracellular region · plasma membrane · cytosol
Rhea
None recorded

Inputs

Outputs

Catalysed by

  • phospholipid transfer activity of MFSD2A [plasma membrane]UniProt Q8NA29

Literature

  1. Inactivating mutations in MFSD2A, required for omega-3 fatty acid transport in brain, cause a lethal microcephaly syndrome Nat. Genet., 2015
  2. Structural insights into the transport mechanism of the human sodium-dependent lysophosphatidylcholine transporter Mfsd2a J. Biol. Chem., 2016
  3. Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid Nature, 2014