MFSD2A transports LPC from extracellular region to plasma membrane
LPC (22:6) + Na+ → LPC (22:6) + Na+
- Reactome
- R-HSA-8865637
- Compartment
- extracellular region · plasma membrane · cytosol
- Rhea
- None recorded
Inputs
- LPC (22:6)CHEBI:64567, C30H50NO7P, extracellular region
- Na+CHEBI:29101, Na, extracellular region
Outputs
- LPC (22:6)CHEBI:64567, C30H50NO7P, cytosol
- Na+CHEBI:29101, Na, cytosol
Catalysed by
- phospholipid transfer activity of MFSD2A [plasma membrane]UniProt Q8NA29
Literature
- Inactivating mutations in MFSD2A, required for omega-3 fatty acid transport in brain, cause a lethal microcephaly syndrome Nat. Genet., 2015
- Structural insights into the transport mechanism of the human sodium-dependent lysophosphatidylcholine transporter Mfsd2a J. Biol. Chem., 2016
- Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid Nature, 2014