1-acyl LPS is acylated to PS by LPSAT
1-acyl LPS + acyl-CoA → PS + CoA-SH
- Reactome
- R-HSA-1482636
- Compartment
- endoplasmic reticulum membrane · cytosol
- Rhea
- RHEA:33191
Inputs
- 1-acyl LPSCHEBI:52603, C7H13NO9PR, endoplasmic reticulum membrane
- acyl-CoACHEBI:58342, C22H31N7O17P3SR, cytosol
Outputs
- PSCHEBI:11750, C8H12NO10PR2, endoplasmic reticulum membrane
- CoA-SHCHEBI:57287, C21H32N7O16P3S, cytosol
Catalysed by
- 1-acylglycerol-3-phosphate O-acyltransferase activity of LPSAT [endoplasmic reticulum membrane]EC 2.3.1.51
Literature
- Discovery of a lysophospholipid acyltransferase family essential for membrane asymmetry and diversity Proc Natl Acad Sci U S A, 2008
- Lysophospholipid acyltransferases and arachidonate recycling in human neutrophils J Biol Chem, 2008
- Molecular identification of a novel mammalian brain isoform of acyl-CoA:lysophospholipid acyltransferase with prominent ethanolamine lysophospholipid acylating activity, LPEAT2 J Biol Chem, 2008