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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

AcCho is hydrolyzed to Cho and acetate by ACHE

AcCho + H2O → Cho + acetate

Reactome: R-HSA-372519
Compartment: extracellular region · plasma membrane
Rhea: RHEA:17562

Inputs

AcChoCHEBI:15355, C7H16NO2, extracellular region
H2OCHEBI:15377, H2O, extracellular region

Outputs

ChoCHEBI:15354, C5H14NO, extracellular region
acetateCHEBI:30089, C2H3O2, extracellular region

Catalysed by

acetylcholinesterase activity of Cholinesterase [plasma membrane]EC 3.1.1.7

Literature

Rational design of a drug for Alzheimer's disease with cholinesterase inhibitory and neuroprotective activity Chem Biol Interact, 2008
The effect of elimination of intersubunit disulfide bonds on the activity, assembly, and secretion of recombinant human acetylcholinesterase. Expression of acetylcholinesterase Cys-580----Ala mutant J Biol Chem, 1991
Structures of recombinant native and E202Q mutant human acetylcholinesterase complexed with the snake-venom toxin fasciculin-II Acta Crystallogr D Biol Crystallogr, 2000