PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane

H2O + PI(3,4)P2 → PI3P + Pi

Reactome

R-HSA-1676162

Compartment

early endosome membrane · cytosol

Rhea

None recorded

Catalysed by

• phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity of INPP4A/B [cytosol]EC 3.1.3.66

Literature

1. The isolation and characterization of cDNA encoding human and rat brain inositol polyphosphate 4-phosphatase J Biol Chem, 1995
2. The cDNA cloning and characterization of inositol polyphosphate 4-phosphatase type II. Evidence for conserved alternative splicing in the 4-phosphatase family J Biol Chem, 1997
3. The type Ialpha inositol polyphosphate 4-phosphatase generates and terminates phosphoinositide 3-kinase signals on endosomes and the plasma membrane Mol Biol Cell, 2005