CDP-Cho and DAG are converted to PC by CHPT1 at the Golgi membrane
CDP-Cho + DAG → CMP + PC
- Reactome
- R-HSA-1482973
- Compartment
- Golgi membrane · cytosol
- Rhea
- RHEA:32939
Inputs
- CDP-ChoCHEBI:16436, C14H26N4O11P2, cytosol
- DAGCHEBI:17815, C5H6O5R2, Golgi membrane
Outputs
- CMPCHEBI:60377, C9H12N3O8P, cytosol
- PCCHEBI:57643, C10H18NO8PR2, Golgi membrane
Catalysed by
- diacylglycerol cholinephosphotransferase activity of CHPT1:Mg2+/Mn2+ [Golgi membrane]EC 2.7.8.2
Literature
- Cloning and expression of a human choline/ethanolaminephosphotransferase: synthesis of phosphatidylcholine and phosphatidylethanolamine Biochem J, 1999
- Cloning, genomic organization, and characterization of a human cholinephosphotransferase J Biol Chem, 2000
- PC and PE synthesis: mixed micellar analysis of the cholinephosphotransferase and ethanolaminephosphotransferase activities of human choline/ethanolamine phosphotransferase 1 (CEPT1) Lipids, 2002
- The major sites of cellular phospholipid synthesis and molecular determinants of Fatty Acid and lipid head group specificity Mol Biol Cell, 2002