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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

Data

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

PITPNM1,2,3 exchange PI for PA

PI + PA → PI + PA

Reactome: R-HSA-8869241
Compartment: cytosol · endoplasmic reticulum membrane · plasma membrane
Rhea: None recorded

Inputs

PICHEBI:57880, C11H16O13PR2, endoplasmic reticulum membrane
PACHEBI:57739, C5H5O8PR2, plasma membrane

Outputs

PICHEBI:57880, C11H16O13PR2, plasma membrane
PACHEBI:57739, C5H5O8PR2, endoplasmic reticulum membrane

Catalysed by

phosphatidylinositol transfer activity of PITPNM1,2,3 [cytosol]

Literature

Phosphatidylinositol-Phosphatidic Acid Exchange by Nir2 at ER-PM Contact Sites Maintains Phosphoinositide Signaling Competence Dev. Cell, 2015
Phosphatidylinositol 4,5-Bisphosphate Homeostasis Regulated by Nir2 and Nir3 Proteins at Endoplasmic Reticulum-Plasma Membrane Junctions J. Biol. Chem., 2015
Identification of a novel family of targets of PYK2 related to Drosophila retinal degeneration B (rdgB) protein Mol. Cell. Biol., 1999
Mutation in the PYK2-binding domain of PITPNM3 causes autosomal dominant cone dystrophy (CORD5) in two Swedish families Eur. J. Hum. Genet., 2007