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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

TNFAIP8 proteins transfer PI(4,5)P2, PI(3,4,5)P3 from cytosolic vesicles to plasma membrane

PI(4,5)P2, PI(3,4,5)P3 → PI(4,5)P2, PI(3,4,5)P3

Reactome: R-HSA-8874470
Compartment: cytoplasmic vesicle membrane · cytosol · plasma membrane
Rhea: RHEA:85915

Inputs

PI(4,5)P2, PI(3,4,5)P3R-ALL-8874484, cytoplasmic vesicle membrane

Outputs

PI(4,5)P2, PI(3,4,5)P3R-ALL-8874460, plasma membrane

Catalysed by

phosphatidylinositol transfer activity of TNFAIP8 proteins [cytosol]

Literature

The TIPE (TNFAIP8) family in inflammation, immunity, and cancer Mol. Immunol., 2011
Identical expression profiling of human and murine TIPE3 protein reveals links to its functions J. Histochem. Cytochem., 2015
TIPE3 is the transfer protein of lipid second messengers that promote cancer Cancer Cell, 2014
A new TIPE of phosphoinositide regulator in cancer Cancer Cell, 2014