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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane

PI3P + H2O → PI + Pi

Reactome: R-HSA-6809325
Compartment: plasma membrane · cytosol
Rhea: RHEA:12316

Inputs

PI3PCHEBI:58088, C11H15O16P2R2, plasma membrane
H2OCHEBI:15377, H2O, cytosol

Outputs

PICHEBI:57880, C11H16O13PR2, plasma membrane
PiCHEBI:43474, HO4P, cytosol

Catalysed by

phosphatidylinositol-3-phosphate phosphatase activity of MTMR6:MTMR9,MTMR8:MTMR9 [cytosol]EC 3.1.3.64

Literature

Myotubularin-related protein (MTMR) 9 determines the enzymatic activity, substrate specificity, and role in autophagy of MTMR8 Proc. Natl. Acad. Sci. U.S.A., 2012