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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

Data

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane

ATP + PI → ADP + PI4P

Reactome: R-HSA-1676185
Compartment: Golgi membrane · cytosol
Rhea: RHEA:19877

Inputs

ATPCHEBI:30616, C10H12N5O13P3, cytosol
PICHEBI:57880, C11H16O13PR2, Golgi membrane

Outputs

ADPCHEBI:456216, C10H12N5O10P2, cytosol
PI4PCHEBI:17526, C11H18O16P2R2, Golgi membrane

Catalysed by

1-phosphatidylinositol 4-kinase activity of PI4KA/2A/2B [cytosol]EC 2.7.1.67

Literature

ARF mediates recruitment of PtdIns-4-OH kinase-beta and stimulates synthesis of PtdIns(4,5)P2 on the Golgi complex Nat Cell Biol, 1999
Characterization of type II phosphatidylinositol 4-kinase isoforms reveals association of the enzymes with endosomal vesicular compartments J Biol Chem, 2002
Cloning of a human type II phosphatidylinositol 4-kinase reveals a novel lipid kinase family J Biol Chem, 2001
Type II phosphatidylinositol 4-kinase beta is a cytosolic and peripheral membrane protein that is recruited to the plasma membrane and activated by Rac-GTP J Biol Chem, 2002
Functional expression and characterisation of a new human phosphatidylinositol 4-kinase PI4K230 Biochim Biophys Acta, 1999