AGK:Mg2+ phosphorylates MAG, DAG
MAG,DAG + ATP → LPA,PA + ADP
- Reactome
- R-HSA-5696074
- Compartment
- mitochondrial outer membrane · mitochondrial intermembrane space
- Rhea
- None recorded
Inputs
- MAG,DAGR-ALL-5696066, mitochondrial intermembrane space
- ATPCHEBI:30616, C10H12N5O13P3, mitochondrial intermembrane space
Outputs
- LPA,PAR-ALL-5696037, mitochondrial intermembrane space
- ADPCHEBI:456216, C10H12N5O10P2, mitochondrial intermembrane space
Catalysed by
- acylglycerol kinase activity of AGK:Mg2+ [mitochondrial outer membrane]EC 2.7.1.94
Literature
- A novel acylglycerol kinase that produces lysophosphatidic acid modulates cross talk with EGFR in prostate cancer cells J. Cell Biol., 2005
- Proteomic mapping of the human mitochondrial intermembrane space in live cells via ratiometric APEX tagging Mol. Cell, 2014
- Congenital cataract and mitochondrial myopathy of skeletal and heart muscle associated with lactic acidosis after exercise J. Pediatr., 1975
- Lack of the mitochondrial protein acylglycerol kinase causes Sengers syndrome Am. J. Hum. Genet., 2012