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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1

PI(3,5)P2 + H2O → PI5P + Pi

Reactome: R-HSA-6809778
Compartment: cytosol · endoplasmic reticulum membrane
Rhea: RHEA:39019

Inputs

PI(3,5)P2CHEBI:57923, C11H14O19P3R2, endoplasmic reticulum membrane
H2OCHEBI:15377, H2O, cytosol

Outputs

PI5PCHEBI:57795, C11H15O16P2R2, endoplasmic reticulum membrane
PiCHEBI:43474, HO4P, cytosol

Catalysed by

phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity of MTMR2:SBF1 [endoplasmic reticulum membrane]EC 3.1.3.95

Literature

Regulation of myotubularin-related (MTMR)2 phosphatidylinositol phosphatase by MTMR5, a catalytically inactive phosphatase Proc. Natl. Acad. Sci. U.S.A., 2003
Membrane association of myotubularin-related protein 2 is mediated by a pleckstrin homology-GRAM domain and a coiled-coil dimerization module Proc. Natl. Acad. Sci. U.S.A., 2003
SBF-1 exerts strong anticervical cancer effect through inducing endoplasmic reticulum stress-associated cell death via targeting sarco/endoplasmic reticulum Ca(2+)-ATPase 2 Cell Death Dis, 2014