PLA2G15 hydrolyses LPC to GPCho and LCFA(-)
lysoPC + H2O → GPCho + LCFA(-)
- Reactome
- R-HSA-8952251
- Compartment
- extracellular region
- Rhea
- None recorded
Inputs
- lysoPCCHEBI:60479, C9H19NO7PR, extracellular region
- H2OCHEBI:15377, H2O, extracellular region
Outputs
- GPChoCHEBI:16870, C8H20NO6P, extracellular region
- LCFA(-)CHEBI:57560, CO2R, extracellular region
Catalysed by
- A2-type glycerophospholipase activity of PLA2G15 [extracellular region]EC 3.1.1.4; UniProt Q8NCC3
Literature
- Cloning and expression of a novel lysophospholipase which structurally resembles lecithin cholesterol acyltransferase Biochem. Biophys. Res. Commun., 1999
- Cloning and characterization of a lysosomal phospholipase A2, 1-O-acylceramide synthase J. Biol. Chem., 2002
- Purification and characterization of 1-O-acylceramide synthase, a novel phospholipase A2 with transacylase activity J. Biol. Chem., 1998