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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

ALPI dimer hydrolyses phosphate monoesters

H2O + phosphate monoester → Pi + Alcohol

Reactome: R-HSA-8878787
Compartment: extracellular region · plasma membrane
Rhea: RHEA:15018

Inputs

H2OCHEBI:15377, H2O, extracellular region
phosphate monoesterCHEBI:7794, H2O4PR, extracellular region

Outputs

PiCHEBI:43474, HO4P, extracellular region
AlcoholCHEBI:30879, HOR, extracellular region

Catalysed by

alkaline phosphatase activity of ALPI:2Ca2+:Mg2+ dimer [plasma membrane]EC 3.1.3.1

Literature

Partial sequencing of human adult, human fetal, and bovine intestinal alkaline phosphatases: comparison with the human placental and liver isozymes Proc. Natl. Acad. Sci. U.S.A., 1986
Alkaline phosphatase: an overview Indian J Clin Biochem, 2014