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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

PI4KB binds to ARF1/3:GTP at the Golgi membrane

ARF1/3:GTP + PI4KB → ARF1/3:GTP:PI4KB

Reactome: R-HSA-1676152
Compartment: Golgi membrane · cytosol
Rhea: None recorded

Inputs

ARF1/3:GTPR-HSA-1806258, Golgi membrane
PI4KBR-HSA-1604615, cytosol

Outputs

ARF1/3:GTP:PI4KBR-HSA-1806287, Golgi membrane

Catalysed by

1-phosphatidylinositol 4-kinase activator activity of ARF1/3:GTP [Golgi membrane]

Literature

Specificity, promiscuity and localization of ARF protein interactions with NCS-1 and phosphatidylinositol-4 kinase-III beta Traffic, 2007
Subcellular locations of phosphatidylinositol 4-kinase isoforms J Biol Chem, 1997
ARF mediates recruitment of PtdIns-4-OH kinase-beta and stimulates synthesis of PtdIns(4,5)P2 on the Golgi complex Nat Cell Biol, 1999