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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

HRASLS transfer acyl group from PC to PE to form NAPE

PC + PE → LysoPtdCho + NAPE

Reactome: R-HSA-8858298
Compartment: cytosol · endoplasmic reticulum membrane
Rhea: None recorded

Inputs

PCCHEBI:57643, C10H18NO8PR2, endoplasmic reticulum membrane
PECHEBI:57613, C7H12NO8PR2, endoplasmic reticulum membrane

Outputs

LysoPtdChoCHEBI:58168, C9H19NO7PR, endoplasmic reticulum membrane
NAPECHEBI:61232, C8H11NO9PR3, endoplasmic reticulum membrane

Catalysed by

acyltransferase activity of HRASLS [cytosol]EC 2.3

Literature

The HRASLS (PLA/AT) subfamily of enzymes J. Biomed. Sci., 2015
Structural basis for the acyltransferase activity of lecithin:retinol acyltransferase-like proteins J. Biol. Chem., 2012
Generation of N-acylphosphatidylethanolamine by members of the phospholipase A/acyltransferase (PLA/AT) family J. Biol. Chem., 2012