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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus

PI(4,5)P2 + H2O → Pi + PI5P

Reactome: R-HSA-6810410
Compartment: nucleoplasm
Rhea: RHEA:25675

Inputs

PI(4,5)P2CHEBI:58456, C11H14O19P3R2, nucleoplasm
H2OCHEBI:15377, H2O, nucleoplasm

Outputs

PiCHEBI:43474, HO4P, nucleoplasm
PI5PCHEBI:57795, C11H15O16P2R2, nucleoplasm

Catalysed by

phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity of TMEM55B [nucleoplasm]EC 3.1.3.78; UniProt Q86T03

Literature

Type I phosphatidylinositol-4,5-bisphosphate 4-phosphatase regulates stress-induced apoptosis Proc. Natl. Acad. Sci. U.S.A., 2007