CL and 1-acyl LPC are converted to MLCL and PC by TAZ (IM) (Reversible)
cardiolipin + 1-acyl LPC → MLCL + PC
- Reactome
- R-HSA-1482794
- Compartment
- mitochondrial inner membrane
- Rhea
- None recorded
Inputs
- cardiolipinCHEBI:28494, C13H18O17P2R4, mitochondrial inner membrane
- 1-acyl LPCCHEBI:17504, C9H20NO7PR, mitochondrial inner membrane
Outputs
- MLCLCHEBI:60430, C12H19O16P2R3, mitochondrial inner membrane
- PCCHEBI:57643, C10H18NO8PR2, mitochondrial inner membrane
Catalysed by
- 1-acylglycerophosphocholine O-acyltransferase activity of TAZ [mitochondrial inner membrane]EC 2.3.1.23; UniProt Q16635
Literature
- Remodeling of cardiolipin by phospholipid transacylation J Biol Chem, 2003
- The enzymatic function of tafazzin J Biol Chem, 2006
- Formation of molecular species of mitochondrial cardiolipin. 1. A novel transacylation mechanism to shuttle fatty acids between sn-1 and sn-2 positions of multiple phospholipid species Biochim Biophys Acta, 2009