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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap
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Nucleotide catabolism

Dephosphorylation, deamination, cleavage and oxidation routes for purines and pyrimidines. 63 reactions, from Reactome R-HSA-8956319.

  1. NT5E:Zn2+ hydrolyses AMP,dAMP,GMP, IMPAMP, dAMP, GMP, IMP + H2O → Ade-Rib, dA, Gua-Rib, Ino + Pi
  2. CMP or TMP or UMP + H2O => cytidine, thymidine, or uridine + orthophosphate [NT5E]CMP, TMP, UMP + H2O → Cyt-Rib, Thy-dRib, Ura-Rib + Pi
  3. (d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C1A)(d)CMP, TMP, (d)UMP + H2O → (d)C, T, (d)U + Pi
  4. (2'-deoxy)purine nucleoside 5'-monophosphate + H2O => (2'-deoxy)purine nucleoside + orthophosphate [NT5C1A](d)AMP, (d)GMP, (d)IMP + H2O → (d)A, (d)G, (d)I + Pi
  5. AMP + H2O => adenosine + orthophosphate [NT5C1B]AMP + H2O → Ade-Rib + Pi
  6. (d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3)(d)CMP, TMP, (d)UMP + H2O → (d)C, T, (d)U + Pi
  7. (d)GMP or (d)IMP + H2O => (d)G or (d)I + orthophosphate (NT5C)(d)GMP, (d)IMP + H2O → Gu-Rib, dG, Ino, dI + Pi
  8. TMP, uridine 2', 3', or 5' monophosphates, or deoxyuridine 3' or 5' monophosphates + H2O => thymidine or (deoxy)uridine + orthophosphate [NT5C]TMP, U2MP, U3MP, UMP, dU3MP, dUMP + H2O → Thy-Rib, (d)U + Pi
  9. TMP, (d)UMP, uridine 2' monophosphate, or uridine 3'-monophosphate + H2O => thymidine, deoxyuridine, or uridine + orthophosphate [NT5M]TMP, UMP, dU5MP, U2MP, U3MP + H2O → Thy-dRib, Ura-Rib, dU + Pi
  10. thymidine or deoxyuridine + orthophosphate thymine or uracil + 2-deoxy-D-ribose 1-phosphate [TYMP]Thy-Rib, dU + Pi → Thy, Ura + dRibP
  11. Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMPADP-D-ribose + H2O → AMP + R5P + 2 H+
  12. Mitochondrial NUDT9 hydrolyses ADP-ribose to R5P and AMPADP-Rib + H2O → AMP + R5P + 2 H+
  13. NUDT1 hydrolyses 2-oxo-dATP to 2-oxo-dAMPH2O + 2-oxo-dATP(4-) → 2-oxo-dAMP(2-) + H+ + PPi
  14. NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMPH2O + 8-oxo-dGTP(4-) → 8-oxo-dGMP(2-) + H+ + PPi
  15. NUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMPH2O + 8-oxo-dGTP(4-) → 8-oxo-dGMP(2-) + H+ + PPi
  16. NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMPH2O + 2-oxo-ATP(4-) → 2-oxo-AMP(2-) + H+ + PPi
  17. NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMPH2O + 8-oxo-GDP(3-) → Pi + 8-oxo-GMP(2-) + H+
  18. NUDT15 hydrolyses 8-oxo-dGDP to 8-oxo-dGMPH2O + 8-oxo-dGDP(3-) → Pi + 8-oxo-dGMP(2-) + H+
  19. NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMPH2O + 8-oxo-dGDP(3-) → Pi + 8-oxo-dGMP(2-) + H+
  20. NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMPH2O + 8-oxo-dADP(3-) → Pi + 8-oxo-dAMP(2-) + H+
  21. NUDT16 hydrolyses dIDP to dIMPdIDP + H2O → dIMP + Pi + H+
  22. NUDT16 hydrolyses IDP to IMPIDP + H2O → IMP + Pi + H+
  23. ITPA hydrolyses ITP to IMPITP + H2O → IMP + PPi + H+
  24. ITPA hydrolyses XTP to XMPXTP + H2O → XMP + PPi + H+
  25. ITPA hydrolyses dITP to dIMPdITP + H2O → PPi + dIMP + H+
  26. ADPRM hydrolyses ADP-ribose to R5P and AMPADP-D-ribose + H2O → R5P + AMP + 2 H+
  27. reduction of uracil to form dihydrouracilUra + NADPH + H+ → 5,6-Dihydrouracil + NADP+
  28. conversion of 5,6-dihydrouracil to 3-ureidopropionate5,6-Dihydrouracil + H2O → UPROP + H+
  29. conversion of 3-ureidopropionate to beta-alanineUPROP + H2O + 2 H+ → b-Ala + CO2 + NH4+
  30. reduction of thymine to form 5,6-DihydrothymineThy + NADPH + H+ → 5,6-Dihydrothymine + NADP+
  31. conversion of 5,6-Dihydrothymine to 3-Ureidoisobutyrate5,6-Dihydrothymine + H2O → UIBA + H+
  32. conversion of 3-Ureidoiosbutyrate to 3-AminoisobutyrateUIBA + H2O + 2 H+ → CO2 + NH4+ + 3AIB
  33. PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribosePi + Ino, dI → Hyp + R1P, dRibP
  34. XDH oxidizes hypoxanthine to form xanthineHyp + H2O + O2 → XAN + H2O2
  35. (d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2)(d)GMP, (d)IMP + H2O → Gu-Rib, dG, Ino, dI + Pi
  36. PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribosePi + G, dG → Gua + R1P, dRibP
  37. Guanine + H2O => Xanthine + NH4+Gua + H2O + H+ → XAN + NH4+
  38. XDH oxidizes xanthine to form urateXAN + H2O + O2 → urate + H2O2
  39. (deoxy)uridine + orthophosphate uracil + (deoxy)ribose 1-phosphate (UPP)(d)Ura + Pi → Ura + R1P, dRibP
  40. NTPDase1 hydrolyzes nucleoside triphosphatesNTP + H2O → NDP + Pi + H+
  41. NTPDase1 hydrolyzes nucleoside diphosphatesNDP + H2O → NMP + Pi + H+
  42. NTPDase2 hydrolyzes nucleoside triphosphatesATP,GTP,CTP,ITP,UTP + H2O → ADP,GDP,CDP,IDP,UDP + Pi + H+
  43. NTPDase3 hydrolyzes nucleoside triphosphatesNTP + H2O → NDP + Pi + H+
  44. NTPDase3 hydrolyzes nucleoside diphosphatesNDP + H2O → NMP + Pi + H+
  45. NTPDase4 hydrolyzes nucleoside diphosphatesUDP,GDP,CDP,dTDP + H2O → UMP,GMP,CMP,dTMP + Pi + H+
  46. NTPDase4 hydrolyzes nucleoside triphosphatesUTP,GTP,CTP,dTTP + H2O → UDP,GDP,CDP,dTDP + Pi + H+
  47. NTPDase5 hydrolyzes nucleoside diphosphatesADP,GDP,CDP,UDP + H2O → AMP,GMP,CMP,UMP + Pi + H+
  48. NTPDase6 hydrolyzes nucleoside diphosphatesCDP,GDP,IDP,UDP + H2O → CMP,GMP,IMP,UMP + Pi + H+
  49. NTPDase7 hydrolyzes nucleoside triphosphatesCTP,GTP,UTP + H2O → CDP,GDP,UDP + Pi + H+
  50. NTPDase8 hydrolyzes nucleoside triphosphatesH2O + ATP,GTP,ITP,CTP,TTP,UTP → Pi + ADP,GDP,IDP,CDP,TDP,UDP + H+
  51. NTPDase8 hydrolyzes nucleoside diphosphatesH2O + ADP,GDP,IDP,CDP,TDP,UDP → Pi + AMP,GMP,IMP,CMP,TMP,UMP + H+
  52. SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphateH2O + dNTP(4-) → 2'-deoxynucleoside + PPPi + H+
  53. DNPH1 hydrolyses dGMPdGMP + H2O → 2DORP + Gua
  54. Mitochondrial uptake of (R)-3-aminoisobutyric acid3AIB → 3AIB
  55. Mitochondrial uptake of beta-alanineb-Ala → b-Ala
  56. beta-alanine + pyruvate => 3-oxopropanoate + alanineb-Ala + PYR → OPROP + L-Ala
  57. (R)-3-amino-2-methylpropanoate + pyruvate => 2-methyl-3-oxopropanoate + L-alanine3AIB + PYR → L-Ala + 2-methyl-3-oxopropanoate
  58. XDH dehydrogenates hypoxanthine to form xanthineH2O + Hyp + NAD+ → H+ + NADH + XAN
  59. XDH dehydrogenates xanthine to form urateH2O + NAD+ + XAN → H+ + NADH + urate
  60. NUDT1 hydrolyses 8-oxo-dATP to 8-oxo-dAMP8-oxo-dATP(4-) + H2O → 8-oxo-dAMP(2-) + H+ + PPi
  61. NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMPH2O + O(6)-methyl-dGTP(4-) → H+ + O(6)-methyl-dGMP(2-) + PPi
  62. NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMPH2O + N(6)-methyl-dATP(4-) → H+ + N(6)-methyl-dAMP(2-) + PPi
  63. NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMPN(6)-methyl-ATP(4-) + H2O → H+ + N(6)-methyl-AMP(2-) + PPi