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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

thymidine or deoxyuridine + orthophosphate thymine or uracil + 2-deoxy-D-ribose 1-phosphate [TYMP]

Thy-Rib, dU + Pi → Thy, Ura + dRibP

Reactome: R-HSA-112265
Compartment: cytosol
Rhea: RHEA:16038, RHEA:22825

Inputs

Thy-Rib, dUR-ALL-500444, cytosol
PiCHEBI:43474, HO4P, cytosol

Outputs

Thy, UraR-ALL-500438, cytosol
dRibPCHEBI:58576, C5H9O7P, cytosol

Catalysed by

pentosyltransferase activity of TYMP dimer [cytosol]EC 2.4.2

Literature

Catabolism of thymidine in human blood platelets: purification and properties of thymidine phosphorylase Biochim Biophys Acta, 1981
Crystal structure of human thymidine phosphorylase in complex with a small molecule inhibitor Structure, 2004
Platelet-derived endothelial cell growth factor has thymidine phosphorylase activity. Biochem Biophys Res Commun, 1992