NTPDase8 hydrolyzes nucleoside triphosphates
H2O + ATP,GTP,ITP,CTP,TTP,UTP → Pi + ADP,GDP,IDP,CDP,TDP,UDP + H+
- Reactome
- R-HSA-8851538
- Compartment
- extracellular region · plasma membrane
Inputs
- H2OCHEBI:15377, H2O, extracellular region
- ATP,GTP,ITP,CTP,TTP,UTPR-ALL-9726184, extracellular region
Outputs
- PiCHEBI:43474, HO4P, extracellular region
- ADP,GDP,IDP,CDP,TDP,UDPR-ALL-9726189, extracellular region
- H+CHEBI:15378, H, extracellular region
Catalysed by
- ribonucleoside triphosphate phosphatase activity of NTPDase8:Ca2+,Mg2+ [plasma membrane]EC 3.6.1.15
Literature
- Cloning, purification, and identification of the liver canalicular ecto-ATPase as NTPDase8 Am. J. Physiol. Gastrointest. Liver Physiol., 2007
- Identification and characterization of a novel hepatic canalicular ATP diphosphohydrolase J. Biol. Chem., 2000