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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

NTPDase4 hydrolyzes nucleoside diphosphates

UDP,GDP,CDP,dTDP + H2O → UMP,GMP,CMP,dTMP + Pi + H+

Reactome: R-HSA-8851225
Compartment: Golgi lumen · Golgi membrane
Rhea: RHEA:64877, RHEA:64881, RHEA:22157, RHEA:64961

Inputs

UDP,GDP,CDP,dTDPR-ALL-8851224, Golgi lumen
H2OCHEBI:15377, H2O, Golgi lumen

Outputs

UMP,GMP,CMP,dTMPR-ALL-8851227, Golgi lumen
PiCHEBI:43474, HO4P, Golgi lumen
H+CHEBI:15378, H, Golgi lumen

Catalysed by

nucleoside diphosphate phosphatase activity of NTPDase4:Ca2+ [Golgi membrane]EC 3.6.1.6

Literature

Golgi localization and functional expression of human uridine diphosphatase J. Biol. Chem., 1998