(2'-deoxy)purine nucleoside 5'-monophosphate + H2O => (2'-deoxy)purine nucleoside + orthophosphate [NT5C1A]
(d)AMP, (d)GMP, (d)IMP + H2O → (d)A, (d)G, (d)I + Pi
- Reactome
- R-HSA-109387
- Compartment
- cytosol
Inputs
- (d)AMP, (d)GMP, (d)IMPR-ALL-500125, cytosol
- H2OCHEBI:15377, H2O, cytosol
Outputs
- (d)A, (d)G, (d)IR-ALL-500124, cytosol
- PiCHEBI:43474, HO4P, cytosol
Catalysed by
- 5'-nucleotidase activity of NT5C1A tetramer [cytosol]EC 3.1.3.5
Literature
- Mammalian 5'-nucleotidases J Biol Chem, 2003
- Human cytosolic 5'-nucleotidase I. Characterization and role in nucleoside analog resistance J Biol Chem, 2001
- The mechanism of adenosine formation in cells. Cloning of cytosolic 5'-nucleotidase-I J Biol Chem, 1999
- Partial purification and properties of an AMP-specific soluble 5'-nucleotidase from pigeon heart Biochem J, 1990