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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap
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Guanine + H2O => Xanthine + NH4+

Gua + H2O + H+ → XAN + NH4+

Reactome
R-HSA-74255
Compartment
cytosol
Rhea
RHEA:14666

Inputs

Outputs

Catalysed by

  • guanine deaminase activity of GDA dimer [cytosol]EC 3.5.4.3

Literature

  1. Cloning and characterization of human guanine deaminase. Purification and partial amino acid sequence of the mouse protein. J Biol Chem, 1999
  2. Alteration of enzyme specificity by computational loop remodeling and design Proc Natl Acad Sci U S A, 2009