NTPDase3 hydrolyzes nucleoside triphosphates
NTP + H2O → NDP + Pi + H+
- Reactome
- R-HSA-8851110
- Compartment
- extracellular region · plasma membrane
- Rhea
- RHEA:23681
Inputs
- NTPCHEBI:61557, C5H8O13P3R, extracellular region
- H2OCHEBI:15377, H2O, extracellular region
Outputs
- NDPCHEBI:57930, C5H8O10P2R, extracellular region
- PiCHEBI:43474, HO4P, extracellular region
- H+CHEBI:15378, H, extracellular region
Catalysed by
- ribonucleoside triphosphate phosphatase activity of NTPDase3:Ca2+,Mg2+ [plasma membrane]EC 3.6.1.15
Literature
- Cloning, sequencing, and expression of a human brain ecto-apyrase related to both the ecto-ATPases and CD39 ecto-apyrases1 Biochim. Biophys. Acta, 1998
- Comparative hydrolysis of P2 receptor agonists by NTPDases 1, 2, 3 and 8 Purinergic Signal., 2005
- Cloning and characterization of mouse nucleoside triphosphate diphosphohydrolase-3 Biochem. Pharmacol., 2004
- Identification of the ectonucleotidases expressed in mouse, rat, and human Langerhans islets: potential role of NTPDase3 in insulin secretion Am. J. Physiol. Endocrinol. Metab., 2010
- Immunolocalization of ecto-nucleoside triphosphate diphosphohydrolase 3 in rat brain: implications for modulation of multiple homeostatic systems including feeding and sleep-wake behaviors Neuroscience, 2006