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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

ITPA hydrolyses ITP to IMP

ITP + H2O → IMP + PPi + H+

Reactome: R-HSA-2509827
Compartment: cytosol
Rhea: RHEA:29400, RHEA:28611

Inputs

ITPCHEBI:61402, C10H11N4O14P3, cytosol
H2OCHEBI:15377, H2O, cytosol

Outputs

IMPCHEBI:58053, C10H11N4O8P, cytosol
PPiCHEBI:33019, HO7P2, cytosol
H+CHEBI:15378, H, cytosol

Catalysed by

ITP diphosphatase activity of ITPA dimer [cytosol]EC 3.6.1.66

ITPA hydrolyses ITP to IMP

Inputs

Outputs

Catalysed by

Literature