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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

DNPH1 hydrolyses dGMP

dGMP + H2O → 2DORP + Gua

Reactome: R-HSA-8953339
Compartment: cytosol
Rhea: RHEA:57817

Inputs

dGMPCHEBI:57673, C10H12N5O7P, cytosol
H2OCHEBI:15377, H2O, cytosol

Outputs

2DORPCHEBI:62877, C5H9O7P, cytosol
GuaCHEBI:16235, C5H5N5O, cytosol

Catalysed by

5-hydroxymethyl-dUMP N-hydrolase activity of DNPH1 [cytosol]EC 3.2.2; UniProt O43598

Literature

N (6)-substituted AMPs inhibit mammalian deoxynucleotide N-hydrolase DNPH1 PLoS ONE, 2013
The c-Myc target gene Rcl (C6orf108) encodes a novel enzyme, deoxynucleoside 5'-monophosphate N-glycosidase J. Biol. Chem., 2007
6-(Hetero)Arylpurine nucleotides as inhibitors of the oncogenic target DNPH1: synthesis, structural studies and cytotoxic activities Eur J Med Chem, 2014